Resources

Contact

Talkback

Study Reports

Population Pharmacokinetics

Drug Discovery

Special Topics

PKWorkshops

Special Topics

WAM - An efficient covariate screening method 

by Ken Kowalski and Matt Hutmacher

Approximate the difference in the objective function between the restricted model and the
full model without having to run each of the restricted models in NONMEM.

EFFICIENT SCREENING OF COVARIATES IN POPULATION MODELS USING WALD’S APPROXIMATION TO THE LIKELIHOOD RATIO TEST

SCREENING COVARIATE MODELS USING WALD'S APPROXIMATION: AN EVALUATION OF THE WAM ALGORITHM ON SEVERAL DATA SETS

SAS Implementation (zip file)

S-Plus Implementation (zip file)

Both Presentations, the SAS Implementation, and the S-Plus Implementation (zip file)

Other Topics

Nonlinear Mixed Effects Model Building (Pinheiro and Bates)

Stepwise Regression News List Discussion