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Population Pharmacokinetic S-Plus Models Click on the links below to download S-Plus population PK modeling scripts. The scripts are in the S-Plus Windows 2000 *.ssc format and can be easily executed on that platform without modification. The examples are written in Version 3.4 of the S programming language and can be run from the command line or from the Windows Script Window. S-Plus Windows 2000 includes Version 3.4 of the S programming language and Version 3.3 of the nlme() function. The examples have generally been extracted and summarized from the work of Jose Pinheiro of Bell Labs and Douglas Bates of the UW-Madison, authors of the nlme function and the book 'Mixed Effects Modeling Using S and S-Plus' .. More examples will be developed and posted during the month of December. You can register for update notification using the form on the Contact page. Please don't forget to complete the Population PK Feedback Form, we can better meet your needs with your feedback. Getting Started You will want to download the general instructions script first, the instructions provide guidance for all the examples available now. The groupedData also provides general guidance. There are two examples showing how to use an S-Plus self-start model function and two that use recursive functions written in C. The C code is also available for reference. Instructions for creating a C dll using Visual C will be posted soon, please contact techsupport@pharmastatsci.com if you need instructions now or if you have any questions about any of the examples. General Instructions general instructions.SSC Grouped Data groupedData.ssc Self-Start Models theophylline self start.ssc - single dose, one compartment, first order absorption, first order elimination, full profile data. indomethacin self start.ssc - single dose, two-compartment, IV dosing, first-order elimination, full profile data. Recursive Models Phenobarb recursive form.ssc - multiple IV dosing, one compartment, first order elimination, sparse data, with covariates. quinidine recursive form.ssc - multiple extravascular dosing, one compartment, first order absorption, first order elimination, with covariates. C code for the examples above. It is not necessary to compile the code, it is provided here as a reference for those interested in reviewing the code and perhaps modifying the code to develop other model functions. Please don't forget to complete the Population PK Feedback Form.
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