Home
Talkback
Resources
PKWorkshops
Contact
Pharmacokinetics
Study Reports
Drug Discovery
Special Topics

 

Resources

Contact

Talkback

Study Reports

Population Pharmacokinetics

Drug Discovery

Special Topics

PKWorkshops

Population Pharmacokinetics

Mixed Effects Modeling Using S-Plus 

You can use the S-Plus nlme() to do mixed effects PK modeling. Many examples are provided,  click on the link below for more information.

Population PK S-Plus Models.

"Mixed Effects Modeling Using S and S-Plus"  Mixed Effects Modeling Using S and S-Plus

Find out about the S Population PKlibrary and download 'pklibrary alpha 1'.  

NEW - Download new PK models parameterized in terms of Cl and V - contributed by In-Sun Nam

NEW - Download more new PK models parameterized in terms of Cl and V - contributed by In-Sun Nam

Model Building and Selection

Special Topics 


NONMEM Users

XPOSE - XPOSE is an S-Plus application written by Mats Karlson and Nichlas Jonsson. You can read in NONMEM output and generate a range of diagnostic plots and carry out useful analysis, including GAM, bootstrap of the GAM,  tree regression, and more.

 

Study Design

Evaluation of Population Fisher Information Matrix - S-PLUS functions to compute the population Fisher information matrix for the evaluation of population pharmacokinetic designs by S. Retout, et al.